Article
Matrix metalloproteinase-9 gene -1562C/T polymorphism mitigates preeclampsia.
Placenta - 1 Jul 2007
Coolman M, de Maat M, Van Heerde W L, Felida L, Schoormans S, Steegers E A P, Bertina R M, de Groot C J M
Abstract excerpt
Although the aetiology of preeclampsia is unknown, there is substantial evidence that it finds its roots in abnormal placentation. Prerequisites for successful placentation include trophoblast invasion, degradation and remodelling of the uterine decidual extracellular matrix, and apoptosis without thrombosis. We tested this hypothesis by analysing the effect of functional polymorphisms in the genes coding for...
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