Article
No evidence for a major role of polymorphisms during bupropion treatment.
Obesity (Silver Spring, Md.) - 1 Nov 2006
Hu Jianfang, Redden David T, Berrettini Wade H, Shields Peter G, Restine Stephanie L, Pinto Angela, Lerman Caryn, Allison David B
Abstract excerpt
This study evaluated the ability of polymorphisms in five candidate genes to predict weight gain among patients taking bupropion or placebo in a smoking cessation trial. Five hundred fifty-three smokers were enrolled into a randomized double-blind, placebo-controlled trial and followed for 12 months. Five candidate genes [DRD2 Taq1 (rs1800497), DRD2-141 (rs1799732), C957T (rs6277), COMT (rs4818), and SLC6A3] were...
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