Article
Regulatory sequences of the PRNP gene influence susceptibility to sporadic Creutzfeldt-Jakob disease.
Neuroscience letters - 16 Jan 2007
Bratosiewicz-Wasik Jolanta, Liberski Pawel P, Golanska Ewa, Jansen Gerhard H, Wasik Tomasz J
Abstract excerpt
The prion diseases are fatal neurodegenerative disorders that afflict both humans and animals. They comprise kuru, Creutzfeldt-Jakob disease (CJD), Gerstmman-Straussler-Scheinker syndrome (GSS), and fatal familial insomnia (FFI). Both GSS, FFI and approximately 10% of CJD cases are genetically linked disorders, whereas 90% of CJD cases are not associated with mutations in the PRNP coding region, therefore other...
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