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Article

Inhibition of signal transducer and activator of transcription 3 activity results in down-regulation of Survivin following irradiation.

Molecular cancer therapeutics - 1 Nov 2006

Kim Kwang Woon, Mutter Robert W, Cao Carolyn, Albert Jeffrey M, Shinohara Eric T, Sekhar Konjeti R, Lu Bo

Abstract excerpt

Signal transducer and activator of transcription 3 (Stat3) and Survivin are constitutively up-regulated in various human tumor cells. We previously found Survivin to be significantly reduced in response to radiation in human umbilical vein endothelial cells (HUVEC) but not in tumor cell lines. In this study, we examined the effect of Stat3 on Survivin expression in irradiated HUVECs and breast cancer cells. We...

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Source

Identifiers

PMID: 17121912
DOI: 10.1158/1535-7163.MCT-06-0261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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