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Article

Radiation promotes malignant phenotypes through SRC in breast cancer cells.

Cancer science - 1 Jan 2015

Kim Rae-Kwon, Cui Yan-Hong, Yoo Ki-Chun, Kim In-Gyu, Lee Minyoung, Choi Yung Hyun, Suh Yongjoon, Lee Su-Jae

Abstract excerpt

Despite the fact that ionizing radiation (IR) is widely used as a standard treatment for breast cancer, much evidence suggests that IR paradoxically promotes cancer malignancy. However, the molecular mechanisms underlying radiation-induced cancer progression remain obscure. Here, we report that irradiation activates SRC signaling among SRC family kinase proteins, thereby promoting malignant phenotypes such as...

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Source

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Identifiers

PMID: 25533622
DOI: 10.1111/cas.12574
PMCID: PMC4317785

Genes

SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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