Article
Imerslund-Grasbeck syndrome associated with recurrent aphthous stomatitis and defective neutrophil function.
Journal of pediatric hematology/oncology - 1 Nov 2006
Broides Arnon, Yerushalmi Baruch, Levy Rachel, Hadad Nurit, Kaplun Norma, Tanner Stephan M, Chapelle Allbert de la, Levy Jacov
Abstract excerpt
Vitamin B(12) deficiency is a well-known cause of recurrent aphthous stomatitis (RAS). However, the mechanism by which this deficiency causes the stomatitis is not well understood. Imerslund-Grasbeck syndrome (IGS) causes vitamin B(12) deficiency and proteinuria due to a defect in the vitamin B(12) receptor. We sought to determine whether the RAS observed in IGS patients is associated with neutrophil dysfunction....
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