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Article

Novel events associated with phenotypic reversion of a P element mutant in Drosophila melanogaster.

Genome - 1 Sept 2006

Anderson Kyle J, Davis Monica M, Hodgetts Ross B

Abstract excerpt

Transposable P elements have been used extensively for Drosophila mutagenesis. While their mutagenic activity has long been recognized, the mechanisms by which P elements cause mutations are varied and not completely understood. We describe here an experiment to replace a P element at vestigial (vg) that caused a strong mutant phenotype (P[21-3]) with a P element (P[21]) known to produce a very weak phenotype...

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Identifiers

PMID: 17110998
DOI: 10.1139/g06-065

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Novel events associated with phenotypic reversion of a P element mutant in Drosophila melanogaster.PMID 17110998Read ↗

The mutant phenotype associated with P-element alleles of the vestigial locus in Drosophila melanogaster may be caused by a readthrough transcript initiated at the P-element promoter.Semantic proximity Read ↗

An intact RNA interference pathway is required for expression of the mutant wing phenotype of vg(21-3), a P-element-induced allele of the vestigial gene in Drosophila.Semantic proximity Read ↗

Protected P-element termini suggest a role for inverted-repeat-binding protein in transposase-induced gap repair in Drosophila melanogaster.Semantic proximity Read ↗

A P element chimera containing captured genomic sequences was recovered at the vestigial locus in Drosophila following targeted transposition.Semantic proximity Read ↗

Prevalence of localized rearrangements vs. transpositions among events induced by Drosophila P element transposase on a P transgene.Semantic proximity Read ↗

P-element mutagenesis.Semantic proximity Read ↗

Genetic evidence for repression of somatic P element movements in Drosophila melanogaster consistent with a role for the KP element.Semantic proximity Read ↗

Repression of hybrid dysgenesis in Drosophila melanogaster by individual naturally occurring P elements.Semantic proximity Read ↗

High-frequency P element loss in Drosophila is homolog dependent.Semantic proximity Read ↗

An unusual genomic position effect on Drosophila white gene expression: pairing dependence, interactions with zeste, and molecular analysis of revertants.Semantic proximity Read ↗

Isolation of true Rbp9 null alleles by imprecise P element excisions.Semantic proximity Read ↗

Rearrangements involving repeated sequences within a P element preferentially occur between units close to the transposon extremities.Semantic proximity Read ↗

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