A novel HLA-B27 allele maps B27 allospecificity to the region around position 70 in the alpha 1 domain.

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A novel HLA-B27 allele maps B27 allospecificity to the region around position 70 in the alpha 1 domain.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1991

Choo S Y, Fan L A, Hansen J A

Abstract excerpt

There are six known HLA-B alleles that share the HLA-B27 allospecificity, yet differ by one to six amino acid substitutions. Each of these B27 alleles can be readily assigned by one of the six representative IEF patterns. Two unrelated individuals, LH and HS, express B27 Ag that appear to be identical by IEF, but an HLA-B27 alloreactive CTL clone I-73 was found to react differently with these cells, suggesting...

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A novel HLA-B27 allele maps B27 allospecificity to the region around position 70 in the alpha 1 domain.

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