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Article

Diminished A gamma T fetal globin levels in Sardinian haplotype II beta 0-thalassaemia patients are associated with a four base pair deletion in the A gamma T promoter.

British journal of haematology - 1 May 1991

Manca L, Cocco E, Gallisai D, Masala B, Gilman J G

Abstract excerpt

In Sardinia, the beta-39 nonsense mutation is the primary cause of beta 0-thalassaemia. This mutation is found mainly on beta-globin gene cluster haplotypes I and II, which differ in their A gamma globin types (A gamma I and A gamma T, respectively). This report presents data on G gamma, A gamma I and A gamma T levels, and the presence or absence of a 4 base pair (bp) deletion at -225 to -222 of the A gamma...

Topics

Base Sequence
Chromosome Deletion
DNA
Fetal Hemoglobin
Globins
Haplotypes
Humans
Italy
Molecular Sequence Data
Mutation
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thalassemia

Source

Identifiers

PMID: 1710478
DOI: 10.1111/j.1365-2141.1991.tb04390.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1710478-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Diminished A gamma T fetal globin levels in Sardinian haplotype II beta 0-thalassaemia patients are associated with a four base pair deletion in the A gamma T promoter.PMID 1710478Read ↗

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