The role of apoptosis in cancer cell survival and therapeutic outcome

Abstract excerpt

A number of discoveries have clarified the molecular mechanism of apoptosis, thus clarifying the link between apoptosis and therapeutic outcome. Even though apoptosis is thought to play a major role in anticancer therapy, the clinical relevance of induction of apoptosis remains uncertain, particularly in solid tumors. Induction of apoptosis by anti-cancer agents has been shown to correlate with tumor response,...

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