Article
High rate multiple drug resistances in HIV-infected patients failing nonnucleoside reverse transcriptase inhibitor regimens in Thailand, where subtype A/E is predominant.
Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) - 1 Dec 2006
Chetchotisakd Ploenchan, Anunnatsiri Siriluck, Kiertiburanakul Sasisopin, Sutthent Ruengpung, Anekthananon Thanomsak, Bowonwatanuwong Chureeratana, Kowadisaiburana Boonchai, Supparatpinyo Khuanchai, Horsakulthai Manassinee, Chasombat Sanchai, Ruxrungtham Kiat
Abstract excerpt
The prevalence of drug resistance was determined among 64 HIV-infected Thai patients who were failed while receiving nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimens. Eighty-nine percent of patients had 1 or more NNRTI mutation resistances. Almost all patients had resistance to at least 1 nucleoside reverse transcriptase inhibitor (NRTI), and 42% had multiple-NRTI resistance.
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