Article
Digenic parkinsonism: investigation of the synergistic effects of PRKN and LRRK2.
Neuroscience letters - 20 Dec 2006
Dächsel Justus C, Mata Ignacio F, Ross Owen A, Taylor Julie P, Lincoln Sarah J, Hinkle Kelly M, Huerta Cecilia, Ribacoba Renee, Blazquez Marta, Alvarez Victoria, Farrer Matthew J
Abstract excerpt
The complex genetic etiology of Parkinson's disease (PD) is indicative of a multifactorial syndrome. A combination of gene-gene and gene-environment interactions may determine a variable phenotypic outcome. Recently a direct gene/protein interaction between two of the most common genetic causes of parkinsonism PRKN and LRRK2 has been postulated. We have identified three Spanish patients simultaneously harboring...
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