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Article

Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2006

Balak Marissa N, Gong Yixuan, Riely Gregory J, Somwar Romel, Li Allan R, Zakowski Maureen F, Chiang Anne, Yang Guangli, Ouerfelli Ouathek, Kris Mark G, Ladanyi Marc, Miller Vincent A, Pao William

Abstract excerpt

PURPOSE: In patients whose lung adenocarcinomas harbor epidermal growth factor receptor (EGFR) tyrosine kinase domain mutations, acquired resistance to the tyrosine kinase inhibitors (TKI) gefitinib (Iressa) and erlotinib (Tarceva) has been associated with a second-site EGFR mutation, which leads to substitution of methionine for threonine at position 790 (T790M). We aimed to elucidate the frequency and nature of...

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Source

Identifiers

PMID: 17085664
DOI: 10.1158/1078-0432.CCR-06-1570

Genes

EGFR
KIT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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