Comparative analysis of gene expression profiles in intact and damaged regions of human osteoarthritic cartilage

Abstract excerpt

OBJECTIVE: To analyze the differences in gene expression profiles of chondrocytes in intact and damaged regions of cartilage from the same knee joint of patients with osteoarthritis (OA) of the knee. METHODS: We compared messenger RNA expression profiles in regions of intact and damaged cartilage (classified according to the Mankin scale) obtained from patients with knee OA. Five pairs of intact and damaged...

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