Article
Influence of the CD14 C260T promoter polymorphism on C-reactive protein levels in patients with coronary artery disease.
The American journal of cardiology - 1 Nov 2006
Bernardo Esther, Angiolillo Dominick J, Ramírez Celia, Cavallari Ugo, Trabetti Elisabetta, Sabaté Manel, Hernández Rosana, Moreno Raul, Escaned Javier, Alfonso Fernando, Bañuelos Camino, Costa Marco A, Bass Theodore A, Pignatti Pier Franco, Macaya Carlos, Fernandez-Ortiz Antonio
Abstract excerpt
The CD14 receptor is an important mediator of inflammatory reactions, and its expression is under genetic control. The allelic variant of the C260T polymorphism located in the promoter region of the CD14 gene is associated with receptor expression and ischemic risk. To date, most studies assessing the functional implications of the C260T polymorphism have been performed under proinflammatory conditions (e.g.,...
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