Article
HLA-DR-negative AML (M1 and M2): FLT3 mutations (ITD and D835) and cell-surface antigen expression.
Leukemia research - 1 Jul 2007
Syampurnawati Meilani, Tatsumi Eiji, Furuta Kaho, Takenokuchi Mariko, Nakamachi Yuji, Kawano Seiji, Kumagai Shunichi, Saigo Katsuyasu, Matsui Toshimitsu, Takahashi Takayuki, Nagai Ken-Ichi, Yabe Hiroki, Kondo Shinichi, Hayashi Yoshitake
Abstract excerpt
FLT3 mutations and cell-surface antigen were investigated in 29 DR-negative (DR(-)) M1/M2 AML samples in comparison with 30 DR-positive (DR(+)) M1/M2 AML samples. FLT3-ITD was detected in 59.3% and D835 was detected in 7.4% of the samples. The incidence of FLT3-ITD was higher in the DR(-) group (59.3%) than in the DR(+) group (17.9%; P=0.002). The DR(-) status was associated with the CD34(-) (82.8%), CD7(-)...
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