Article
Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study.
The Lancet. Neurology - 1 Nov 2006
Barcellos Lisa F, Kamdar Brinda B, Ramsay Patricia P, DeLoa Cari, Lincoln Robin R, Caillier Stacy, Schmidt Silke, Haines Jonathan L, Pericak-Vance Margaret A, Oksenberg Jorge R, Hauser Stephen L
Abstract excerpt
BACKGROUND: Autoimmune mechanisms are thought to have a major role in the pathogenesis of multiple sclerosis. We aimed to identify coexisting autoimmune phenotypes in patients with multiple sclerosis from families with several members with the disease and in their first-degree relatives. METHODS: A total of 176 families (386 individuals and 1107 first-degree relatives) were characterised for a history of other...
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