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Article

Genetic variants of the P-glycoprotein gene Abcb1b modulate opioid-induced hyperalgesia, tolerance and dependence.

Pharmacogenetics and genomics - 1 Nov 2006

Liang De-Yong, Liao Guochun, Lighthall Geoff K, Peltz Gary, Clark David J

Abstract excerpt

OBJECTIVE: Opioid-induced hyperalgesia (OIH) is a state of paradoxically increased nociceptive sensitivity seen in both humans and rodents following the resolution of the acute opioid antinociceptive effects or during periods of chronic opioid administration. Using the power of genetic analysis,...

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Identifiers

PMID: 17047491
DOI: 10.1097/01.fpc.0000236321.94271.f8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17047491-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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