Article
Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase.
Proceedings of the National Academy of Sciences of the United States of America - 24 Oct 2006
Williams Karen D, Busto Macarena, Suster Maximiliano L, So Anthony K-C, Ben-Shahar Yehuda, Leevers Sally J, Sokolowski Marla B
Abstract excerpt
This study links natural variation in a Drosophila melanogaster overwintering strategy, diapause, to the insulin-regulated phosphatidylinositol 3-kinase (PI3-kinase) gene, Dp110. Variation in diapause, a reproductive arrest, was associated with Dp110 by using Dp110 deletions and genomic rescue fragments in transgenic flies. Deletions of Dp110 increased the proportion of individuals in diapause, whereas expression...
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