Article
Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans.
Proceedings of the National Academy of Sciences of the United States of America - 17 Oct 2006
Pellegata Natalia S, Quintanilla-Martinez Leticia, Siggelkow Heide, Samson Elenore, Bink Karin, Höfler Heinz, Fend Falko, Graw Jochen, Atkinson Michael J
Abstract excerpt
MENX is a recessive multiple endocrine neoplasia-like syndrome in the rat. The tumor spectrum in MENX overlaps those of human multiple endocrine neoplasia (MEN) types 1 and 2. We mapped the MenX locus to the distal part of rat chromosome 4, excluding the homologs of the genes responsible for the MEN syndromes (RET and MEN1) and syndromes with an endocrine tumor component (VHL and NF1). We report the fine mapping...
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