Article
Relative contribution of genetic and nongenetic modifiers to intestinal obstruction in cystic fibrosis.
Gastroenterology - 1 Oct 2006
Blackman Scott M, Deering-Brose Rebecca, McWilliams Rita, Naughton Kathleen, Coleman Barbara, Lai Teresa, Algire Marilyn, Beck Suzanne, Hoover-Fong Julie, Hamosh Ada, Fallin M Daniele, West Kristen, Arking Dan E, Chakravarti Aravinda, Cutler David J, Cutting Garry R
Abstract excerpt
BACKGROUND & AIMS: Neonatal intestinal obstruction (meconium ileus [MI]) occurs in 15% of patients with cystic fibrosis (CF). Our aim was to determine the relative contribution of genetic and nongenetic modifiers to the development of this major complication of CF. METHODS: A total of 65 monozygous twin pairs, 23 dizygous twin/triplet sets, and 349 sets of siblings with CF were analyzed for MI status, significant...
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