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Article

MEKK1 is required for MPK4 activation and regulates tissue-specific and temperature-dependent cell death in Arabidopsis.

The Journal of biological chemistry - 1 Dec 2006

Ichimura Kazuya, Casais Catarina, Peck Scott C, Shinozaki Kazuo, Shirasu Ken

Abstract excerpt

Innate immunity signaling pathways in both animals and plants are regulated by mitogen-activated protein kinase (MAPK) cascades. An Arabidopsis MAPK cascade (MEKK1, MKK4/MKK5, and MPK3/MPK6) has been proposed to function downstream of the flagellin receptor FLS2 based on biochemical assays using transient overexpression of candidate components. To genetically test this model, we characterized two mekk1 mutants....

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PMID: 17023433
DOI: 10.1074/jbc.M605319200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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MEKK1 is required for MPK4 activation and regulates tissue-specific and temperature-dependent cell death in Arabidopsis.PMID 17023433Read ↗

MEKK1 is required for flg22-induced MPK4 activation in Arabidopsis plants.Semantic proximity Read ↗

BRASSINOSTEROID-SIGNALING KINASE1 Phosphorylates MAPKKK5 to Regulate Immunity in Arabidopsis.Semantic proximity Read ↗

Chemical-sensitized MITOGEN-ACTIVATED PROTEIN KINASE 4 provides insights into its functions in plant growth and immunity.Semantic proximity Read ↗

The Arabidopsis MAP kinase kinase MKK1 participates in defence responses to the bacterial elicitor flagellin.Semantic proximity Read ↗

Arabidopsis MKS1 is involved in basal immunity and requires an intact N-terminal domain for proper function.Semantic proximity Read ↗

Genetic interaction and phenotypic analysis of the Arabidopsis MAP kinase pathway mutations mekk1 and mpk4 suggests signaling pathway complexity.Semantic proximity Read ↗

Arabidopsis PP2C clade B members are negative feedback regulators of MPK3/MPK6 MAPK cascade in plant immunity and development.Semantic proximity Read ↗

Deletion of a tandem gene family in Arabidopsis: increased MEKK2 abundance triggers autoimmunity when the MEKK1-MKK1/2-MPK4 signaling cascade is disrupted.Semantic proximity Read ↗

Quantitative Phosphoproteomic Analysis Reveals Shared and Specific Targets of Arabidopsis Mitogen-Activated Protein Kinases (MAPKs) MPK3, MPK4, and MPK6.Semantic proximity Read ↗

Arabidopsis MAP kinase 4 regulates gene expression through transcription factor release in the nucleus.Semantic proximity Read ↗

BR-SIGNALING KINASE1 physically associates with FLAGELLIN SENSING2 and regulates plant innate immunity in Arabidopsis.Semantic proximity Read ↗

Arabidopsis MPK3 and MPK6 play different roles in basal and oligogalacturonide- or flagellin-induced resistance against Botrytis cinerea.Semantic proximity Read ↗

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