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Article

Activation of Akt independent of PTEN and CTMP tumor-suppressor gene mutations in epilepsy-associated Taylor-type focal cortical dysplasias.

Acta neuropathologica - 1 Dec 2006

Schick Volker, Majores Michael, Engels Gudrun, Spitoni Sylvia, Koch Arend, Elger Christian E, Simon Matthias, Knobbe Christiane, Blümcke Ingmar, Becker Albert J

Abstract excerpt

Focal cortical dysplasias (FCD) with Taylor-type balloon cells (FCD(IIb)) are frequently observed in biopsy specimens of patients with pharmacoresistant focal epilepsies. The molecular pathogenesis of FCD(IIb), which lack familial inheritance, is only poorly understood. Due to their highly differentiated, malformative nature and glioneuronal phenotype, FCD(IIb) share neuropathological characteristics with lesions...

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Source

Identifiers

PMID: 17013611
DOI: 10.1007/s00401-006-0128-y

Genes

PTEN
TSC1
TSC2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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