Article
Use of Routinely Collected Amniotic Fluid for Whole-Genome Expression Analysis of Polygenic Disorders
28 Sept 2006
Abstract excerpt
BACKGROUND: Neural tube defects related to polygenic disorders are the second most common birth defects in the world, but no molecular biologic tests are available to analyze the genes involved in the pathomechanism of these disorders. We explored the use of routinely collected amniotic fluid to characterize the differential gene expression profiles of polygenic disorders. METHODS: We used oligonucleotide...
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