Article
Impact of a CART promoter genetic variation on plasma lipid profile in a general population.
Molecular genetics and metabolism - 1 Feb 2007
Vasseur Francis, Guérardel Audrey, Barat-Houari Mouna, Cottel Dominique, Amouyel Philippe, Froguel Philippe, Helbecque Nicole
Abstract excerpt
The cocaine and amphetamine regulated transcript (CART), an anorexigenic peptide responding to leptin, is expressed in various areas of the hypothalamus. The role of CART in humans and its potential contribution to abnormalities in feeding control are mostly unknown. Since CART plays an important role in the hypothalamic regulation of energy balance by reducing food intake and increasing lipid substrate...
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