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Article

Bim and Bad mediate imatinib-induced killing of Bcr/Abl <sup>+</sup> leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic

22 Sept 2006

Abstract excerpt

Cell killing is a critical pharmacological activity of imatinib to eradicate Bcr/Abl+ leukemias. We found that imatinib kills Bcr/Abl+ leukemic cells by triggering the Bcl-2-regulated apoptotic pathway. Imatinib activated several proapoptotic BH3-only proteins: bim and bmf transcription was increased, and both Bim and Bad were activated posttranslationally. Studies using RNAi and cells from gene-targeted mice...

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PMID: 16997913
DOI: 10.1073/pnas.0606176103

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Bim and Bad mediate imatinib-induced killing of Bcr/Abl <sup>+</sup> leukemic cells, and resistance due to their loss is overcome by a BH3 mimeticPMID 16997913Read ↗

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