Immunochemical, molecular genetic, and transmission studies on a case of Gerstmann-Sträussler-Scheinker syndrome.

doi:10.1212/wnl.40.10.1578

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Article

Immunochemical, molecular genetic, and transmission studies on a case of Gerstmann-Sträussler-Scheinker syndrome.

Neurology - 1 Oct 1990

Tateishi J, Kitamoto T, Doh-ura K, Sakaki Y, Steinmetz G, Tranchant C, Warter J M, Heldt N

Abstract excerpt

Using immunostaining with anti-prion protein (PrP) antiserum, we detected numerous kuru plaques in the brain of a 24-year-old man with Gerstmann-Sträussler-Scheinker syndrome. Immunoreactivity on Western blotting of the protease-resistant PrP fraction from the frozen brain was weak. PrP gene anal...

Topics

Adult
Alleles
Blotting, Western
Genes
Gerstmann-Straussler-Scheinker Disease
Humans
Immunohistochemistry
Male
Molecular Biology
PrPSc Proteins
Prions
Staining and Labeling
Viral Proteins

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