Article
A prion protein missense variant is integrated in kuru plaque cores in patients with Gerstmann-Sträussler syndrome.
Neurology - 1 Feb 1991
Kitamoto T, Yamaguchi K, Doh-ura K, Tateishi J
Abstract excerpt
Kuru plaques are the pathologic hallmark in Gerstmann-Sträussler syndrome (GSS). To demonstrate that prion protein (PrP) is a component of kuru plaque cores, we fractionated and sequenced kuru plaque core derived peptides, following digestion with Achromobacter lyticus protease I. We identified 3...
Topics
- Amino Acid Sequence
- Chromatography, High Pressure Liquid
- Creutzfeldt-Jakob Syndrome
- Genetic Variation
- Gerstmann-Straussler-Scheinker Disease
- Humans
- PrPSc Proteins
- Prions
- Viral Proteins