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Article

Preproenkephalin hypermethylation in the pure pancreatic juice compared with p53 mutation in the diagnosis of pancreatic carcinoma.

Journal of gastroenterology - 1 Aug 2006

Ohtsubo Koushiro, Watanabe Hiroyuki, Yao Fan, Okada Gensaku, Mouri Hisatsugu, Yamaguchi Yasushi, Sawabu Norio

Abstract excerpt

BACKGROUND: Aberrant methylation of CpG islands is a common mechanism for the dysregulation of tumor suppressor genes in a variety of human malignancies. Preproenkephalin ppENK) hypermethylation is recognized in 90% of pancreatic carcinoma (PCa) tissues, but not in normal pancreas. We analyzed ppENK hypermethylation in pure pancreatic juice (PPJ) in patients with PCa, intraductal papillary mucinous neoplasms...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, p53

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Share to Pancreatitis, Chronic

Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 16988769
DOI: 10.1007/s00535-006-1857-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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