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Article

A novel signal transduction system and feedback loop regulate fructan hydrolase gene expression in Streptococcus mutans.

Molecular microbiology - 1 Oct 2006

Zeng Lin, Wen Zezhang T, Burne Robert A

Abstract excerpt

The fruA gene of Streptococcus mutans encodes for a secreted fructan hydrolase (fructanase), an established virulence determinant required for releasing D-fructose from levan- and inulin-type fructans. Expression of fruA is under the control of carbon catabolite repression and is induced by growth in fructans. In this report, we identified an operon in S. mutans UA159 encoding a two-component system flanked by...

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PMID: 16987177
DOI: 10.1111/j.1365-2958.2006.05359.x

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