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Article

Identification of variations in the human phosphoinositide 3‐kinase <i>p110δ</i> gene in children with primary B‐cell immunodeficiency of unknown aetiology

18 Sept 2006

Abstract excerpt

Our recent study demonstrated that defects in p110delta result in B-cell immunodeficiency that is very similar to that observed in BTK-deficient mice. We revealed that the p110delta fit the B-cell signal transduction complex and played a non-redundant role in the development and function of B cells. In humans, most children with primary B-cell immunodeficiency have mutations in the BTK, whereas a few have defects...

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Identifiers

PMID: 16984281
DOI: 10.1111/j.1744-313x.2006.00627.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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