Article
Structural basis for regioselectivity and stereoselectivity of product formation by naphthalene 1,2-dioxygenase.
Journal of bacteriology - 1 Oct 2006
Ferraro Daniel J, Okerlund Adam L, Mowers Jonathan C, Ramaswamy S
Abstract excerpt
Rieske oxygenase (RO) systems are two- and three-component enzyme systems that catalyze the formation of cis-dihydrodiols from aromatic substrates. Degradation of pollutants in contaminated soil and generation of chiral synthons have been the major foci of RO research. Substrate specificity and product regio- and stereoselectivity have been shown to vary between individual ROs. While directed evolution methods...
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