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Article

Sequencing analysis of ghrelin gene 5' flanking region: relations between the sequence variants, fasting plasma total ghrelin concentrations, and body mass index.

Metabolism: clinical and experimental - 1 Oct 2006

Vartiainen Johanna, Kesäniemi Y Antero, Ukkola Olavi

Abstract excerpt

Ghrelin is a 28-amino-acid peptide with several functions linked to energy metabolism. Low ghrelin plasma concentrations are associated with obesity, hypertension, and type 2 diabetes mellitus, whereas high concentrations reflect states of negative energy balance. Several studies addressing the hormonal and neural regulation of ghrelin gene expression have been carried out, but the role of genetic factors in the...

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PMID: 16979415
DOI: 10.1016/j.metabol.2006.06.014

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