Article
No allelic association or interaction of three known functional polymorphisms with bipolar disorder in a northern Swedish isolated population.
Psychiatric genetics - 1 Oct 2006
Van Den Bogaert Ann, Sleegers Kristel, De Zutter Sonia, Heyrman Lien, Norrback Karl-Fredrik, Adolfsson Rolf, Van Broeckhoven Christine, Del-Favero Jurgen
Abstract excerpt
Most genetic association studies in bipolar disorder have focussed on genes involved in major neurotransmitter systems or brain development. Functional polymorphisms in the serotonin transporter (5-HTTLPR), catechol-O-methyltransferase (Val158Met) and dopamine D3 receptor (Ser9Gly) genes have all been associated with bipolar disorder. We aimed at investigating whether these functional variants contribute to the...
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