Article
Alpha1-antichymotrypsin gene (SERPINA3) A/T polymorphism as a risk factor for aneurysmal subarachnoid hemorrhage.
Stroke - 1 Apr 2005
Slowik Agnieszka, Borratynska Anna, Turaj Wojciech, Pera Joanna, Dziedzic Tomasz, Figlewicz Denise A, Betlej Marek, Krzyszkowski Tadeusz, Czepko Ryszard, Szczudlik Andrzej
Abstract excerpt
BACKGROUND AND PURPOSE: The member 3 of clade A of serine proteinase inhibitors (SERPINA3), known previously as the alpha1-antichymotrypsin, is an acute phase protein, the levels of which increase in acute and chronic inflammation. The A/T polymorphism of the SERPINA3 gene influences expression of SERPINA3 protein. SERPINA3 can be related to aneurysmal subarachnoid hemorrhage (SAH) by influencing inflammation or...
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