Article
Monoclonal antibodies to the bovine immunoglobulin G2a allotypes A1 and A2.
Animal genetics - 1 Jan 1990
Estes D M, Templeton J W, Adams L J
Abstract excerpt
Production of murine monoclonal antibodies (Mabs) to bovine IgG2a-A1 and A2 allotypes resulted in three Mabs being selected as anti-IgG2a-A1 and A2 reagents. Two Mabs recognize the A1 allotype and 1 recognizes the A2 allotype. Initial epitope mapping with the Mabs indicates that one of the A1 epitopes resides in the hinge region and the other epitope resides more toward the C-terminus of the immunoglobulin. The...
Topics
- Alleles
- Animals
- Antibodies, Monoclonal
- Cattle
- Enzyme-Linked Immunosorbent Assay
- Epitopes
- Hybridomas
- Immunoglobulin Allotypes
- Immunoglobulin G
- In Vitro Techniques
- Mice