Article
The myelodysplastic syndromes: biology and implications for management.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Aug 1990
List A F, Garewal H S, Sandberg A A
Abstract excerpt
Since the initial efforts to characterize the myelodysplastic syndromes in 1976, an extensive body of information has accumulated defining biologic features and the relation to clinical aspects of disease. While the pathogenesis of these disorders remains incompletely understood, laboratory investigations indicate that they are clonal disorders affecting hematopoietic stem cells characterized by a progressive...
Topics
- Bone Marrow Transplantation
- Chromosome Aberrations
- Colony-Stimulating Factors
- Genes, ras
- Granulocyte Colony-Stimulating Factor
- Granulocyte-Macrophage Colony-Stimulating Factor
- Growth Substances
- Hematopoiesis
- Humans
- Mutation