Article
Phase distribution of spliceosomal introns: implications for intron origin.
BMC evolutionary biology - 8 Sept 2006
Nguyen Hung D, Yoshihama Maki, Kenmochi Naoya
Abstract excerpt
BACKGROUND: The origin of spliceosomal introns is the central subject of the introns-early versus introns-late debate. The distribution of intron phases is non-uniform, with an excess of phase-0 introns. Introns-early explains this by speculating that a fraction of present-day introns were present between minigenes in the progenote and therefore must lie in phase-0. In contrast, introns-late predicts that the...
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