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Article

Lysine-oriented charges trigger the membrane binding and activity of nukacin ISK-1.

Applied and environmental microbiology - 1 Sept 2006

Asaduzzaman Sikder M, Nagao Jun-Ichi, Aso Yuji, Nakayama Jiro, Sonomoto Kenji

Abstract excerpt

The antibacterial activities and membrane binding of nukacin ISK-1 and its fragments and mutants were evaluated to delineate the determinants governing structure-function relationships. The tail region (nukacin(1-7)) and ring region (nukacin(7-27)) were shown to have no antibacterial activity and also had no synergistic effect on each other or even on nukacin ISK-1. Both a fragment with three lysines in the N...

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Identifiers

PMID: 16957223
DOI: 10.1128/AEM.00678-06
PMCID: PMC1563653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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