Article
Detection of hepatitis B virus (HBV) genotype E carried--even in the presence of high titers of anti-HBs antibodies--by an Argentinean patient of African descent who had received vaccination against HBV.
Journal of clinical microbiology - 1 Sept 2006
Mathet Verónica L, Cuestas María L, Ruiz Vanesa, Minassian María L, Rivero Cintia, Trinks Julieta, Daleoso Graciela, León Liliana M, Sala Andrea, Libellara Beatriz, Corach Daniel, Oubiña José R
Abstract excerpt
Genotype E hepatitis B virus (HBV) was detected in two Argentine sisters exhibiting an African mitochondrial lineage. One of them (who had been vaccinated against HBV) exhibited anti-HBs cocirculating antibodies without HBsAg escape mutants, while her unvaccinated sister showed a D144A HBsAg escape mutant without anti-HBs antibodies. Both sisters carried an unusual L209V substitution within HBsAg.
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