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Article

Crystal structures of the AppA BLUF domain photoreceptor provide insights into blue light-mediated signal transduction.

Journal of molecular biology - 29 Sept 2006

Jung Astrid, Reinstein Jochen, Domratcheva Tatiana, Shoeman Robert L, Schlichting Ilme

Abstract excerpt

Proteins containing a sensor of blue light using FAD (BLUF) domain control diverse cellular processes, such as gene expression, nucleotide metabolism and motility, by relaying blue light signals to distinct output units. Despite its crucial and widespread functions, the mechanism of BLUF signal transduction has remained elusive. We determined crystal structures of the dark-adapted state and of a photo-excited,...

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Identifiers

PMID: 16949615
DOI: 10.1016/j.jmb.2006.07.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Crystal structures of the AppA BLUF domain photoreceptor provide insights into blue light-mediated signal transduction.PMID 16949615Read ↗

The critical role of a hydrogen bond between Gln63 and Trp104 in the blue-light sensing BLUF domain that controls AppA activity.Semantic proximity Read ↗

Electron transfer quenching in light adapted and mutant forms of the AppA BLUF domain.Semantic proximity Read ↗

Structural refinement of a key tryptophan residue in the BLUF photoreceptor AppA by ultraviolet resonance Raman spectroscopy.Semantic proximity Read ↗

Spectroscopic studies of the AppA BLUF domain from Rhodobacter sphaeroides: addressing movement of tryptophan 104 in the signaling state.Semantic proximity Read ↗

Tryptophan at position 104 is involved in transforming light signal into changes of beta-sheet structure for the signaling state in the BLUF domain of AppA.Semantic proximity Read ↗

Structure of a cyanobacterial BLUF protein, Tll0078, containing a novel FAD-binding blue light sensor domain.Semantic proximity Read ↗

A Q63E Rhodobacter sphaeroides AppA BLUF domain mutant is locked in a pseudo-light-excited signaling state.Semantic proximity Read ↗

Structure and insight into blue light-induced changes in the BlrP1 BLUF domain.Semantic proximity Read ↗

Serine in BLUF domains displays spectral importance in computational models.Semantic proximity Read ↗

Ultrafast structural dynamics in BLUF domains: transient infrared spectroscopy of AppA and its mutants.Semantic proximity Read ↗

Residue alterations within a conserved hydrophobic pocket influence light, oxygen, voltage photoreceptor dark recovery.Semantic proximity Read ↗

BlsA Is a Low to Moderate Temperature Blue Light Photoreceptor in the Human Pathogen Acinetobacter baumanniiSemantic proximity Read ↗

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