The antigenic structure of HBsAg: study of the d/y subtype determinant by chemical modification and site directed mutagenesis.

doi:10.1016/0161-5890(90)90168-y

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Article

The antigenic structure of HBsAg: study of the d/y subtype determinant by chemical modification and site directed mutagenesis.

Molecular immunology - 1 May 1990

Guerrero E, Swenson P D, Hu P S, Peterson D L

Abstract excerpt

Lysine residue 122 of the major protein of HBsAg/adw has been shown previously to be involved in the d subtype determinant. We demonstrate here that the corresponding residue of the HBsAg/ayw, arginine 122, does not play such a critical role the y site of this antigen subtype. Thus, conversion by...

Topics

Antibodies, Monoclonal
Antibody Specificity
Arginine
Base Sequence
Cyclohexanones
Epitopes
Hepatitis B Surface Antigens
Humans
Lysine
Methylurea Compounds
Molecular Sequence Data
Mutation
Phenylglyoxal
Serotyping

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