Article
Phenotypic screening of hepatocyte nuclear factor (HNF) 4-gamma receptor knockout mice.
Biochemical and biophysical research communications - 20 Oct 2006
Gerdin Anna Karin, Surve Vikas V, Jönsson Marie, Bjursell Mikael, Björkman Maria, Edenro Anne, Schuelke Meint, Saad Alaa, Bjurström Sivert, Lundgren Elisabeth Jensen, Snaith Michael, Fransson-Steen Ronny, Törnell Jan, Berg Anna-Lena, Bohlooly-Y Mohammad
Abstract excerpt
Using the mouse as a model organism in pharmaceutical research presents unique advantages as its physiology in many ways resembles the human physiology, it also has a relatively short generation time, low breeding and maintenance costs, and is available in a wide variety of inbred strains. The ability to genetically modify mouse embryonic stem cells to generate mouse models that better mimic human disease is...
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