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Article

Characterization of CPAF critical residues and secretion during Chlamydia trachomatis infection.

Infection and immunity - 1 Jun 2015

Yang Zhangsheng, Tang Lingli, Sun Xin, Chai Jijie, Zhong Guangming

Abstract excerpt

CPAF (chlamydial protease-like activity factor), a Chlamydia serine protease, is activated via proximity-induced intermolecular dimerization that triggers processing and removal of an inhibitory peptide occupying the CPAF substrate-binding groove. An active CPAF is a homodimer of two identical intramolecular heterodimers, each consisting of 29-kDa N-terminal and 35-kDa C-terminal fragments. However, critical...

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Identifiers

PMID: 25776755
DOI: 10.1128/IAI.00275-15
PMCID: PMC4432759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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