Article
Characterization of CPAF critical residues and secretion during Chlamydia trachomatis infection.
Infection and immunity - 1 Jun 2015
Yang Zhangsheng, Tang Lingli, Sun Xin, Chai Jijie, Zhong Guangming
Abstract excerpt
CPAF (chlamydial protease-like activity factor), a Chlamydia serine protease, is activated via proximity-induced intermolecular dimerization that triggers processing and removal of an inhibitory peptide occupying the CPAF substrate-binding groove. An active CPAF is a homodimer of two identical intramolecular heterodimers, each consisting of 29-kDa N-terminal and 35-kDa C-terminal fragments. However, critical...
Topics
- Amino Acid Sequence
- Chlamydia Infections
- Chlamydia trachomatis
- Endopeptidases
- Gene Expression Regulation, Bacterial
- HeLa Cells
- Humans
- Mutation