Article
A mitotically inheritable unit containing a MAP kinase module.
Proceedings of the National Academy of Sciences of the United States of America - 5 Sept 2006
Kicka Sébastien, Bonnet Crystel, Sobering Andrew K, Ganesan Latha P, Silar Philippe
Abstract excerpt
Prions are novel kinds of hereditary units, relying solely on proteins, that are infectious and inherited in a non-Mendelian fashion. To date, they are either based on autocatalytic modification of a 3D conformation or on autocatalytic cleavage. Here, we provide further evidence that in the filamentous fungus Podospora anserina, a MAP kinase cascade is probably able to self-activate and generate C, a hereditary...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.