Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dimerization of human immunodeficiency virus type 1 reverse transcriptase. A target for chemotherapeutic intervention.

1 Jun 1990

Abstract excerpt

Recombinant human immunodeficiency virus type 1 reverse transcriptase has been used to investigate the process of dimer formation and the properties of the different mono- and dimeric forms of the enzyme. The studies show that reverse transcriptase activity is exclusively confined to the dimeric forms. As we also demonstrate, the association rate constant between the monomers is relatively low so that the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical and Molecular Research
Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1693146
DOI: 10.1016/s0021-9258(19)38799-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Dimerization of human immunodeficiency virus type 1 reverse transcriptase. A target for chemotherapeutic intervention.PMID 1693146Read ↗

Mutations that abrogate human immunodeficiency virus type 1 reverse transcriptase dimerization affect maturation of the reverse transcriptase heterodimer.Semantic proximity Read ↗

Small molecule inhibitors targeting HIV-1 reverse transcriptase dimerization.Semantic proximity Read ↗

Association between disruption of CD4 receptor dimerization and increased human immunodeficiency virus type 1 entry.Semantic proximity Read ↗

Relationship between enzyme activity and dimeric structure of recombinant HIV-1 reverse transcriptase.Semantic proximity Read ↗

Kinetic mechanism of the DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase.Semantic proximity Read ↗

Mathematical Modelling of the Molecular Mechanisms of Interaction of Tenofovir with Emtricitabine against HIVSemantic proximity Read ↗

Inhibition of human immunodeficiency virus reverse transcriptase by synadenol triphosphate and its E-isomer.Semantic proximity Read ↗

Clofarabine 5'-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit.Semantic proximity Read ↗

Drug resistance mutations can effect dimer stability of HIV-1 protease at neutral pH.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.