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Article

Small molecule inhibitors targeting HIV-1 reverse transcriptase dimerization.

Chembiochem : a European journal of chemical biology - 14 Apr 2008

Grohmann Dina, Corradi Valentina, Elbasyouny Mira, Baude Annika, Horenkamp Florian, Laufer Sandra D, Manetti Fabrizio, Botta Maurizio, Restle Tobias

Abstract excerpt

The enzymatic activities of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) are strictly correlated with the dimeric forms of this vital retroviral enzyme. Accordingly, the development of inhibitors targeting the dimerization of RT represents a promising alternative antiviral strategy. Based on mutational studies, we applied a structure-based ligand design approach generating pharmacophoric...

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Identifiers

PMID: 18318036
DOI: 10.1002/cbic.200700669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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