Article
The prospects of pharmacotherapy for cystic fibrosis.
Journal of the Royal Society of Medicine - 1 Jan 2006
Cuthbert Alan W
Abstract excerpt
To summarize, no effective treatment by drugs is available for CF at the present time. Nevertheless, until a decade ago there were virtually no compounds known that could activate CFTR, whereas today there are many different chemical structures having this property. Much has been learned about molecular pharmacology of CFTR and its most common mutant, deltaF508 CFTR, that will provide new insights for drug...
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