Article
Genetically determined lack of CD45R- T cells in healthy individuals. Evidence for a regulatory polymorphism of CD45R antigen expression.
The Journal of experimental medicine - 1 May 1990
Schwinzer R, Wonigeit K
Abstract excerpt
A genetic polymorphism of CD45R expression was identified resulting in a lack of CD45R- lymphocytes in approximately 8% of healthy individuals. Family studies revealed an autosomal dominant mode of inheritance of the variant CD45R expression pattern. PBMC from donors possessing the variant type d...
Topics
- Antibodies, Monoclonal
- Antigens, CD
- Antigens, Differentiation
- Cells, Cultured
- Epitopes
- Female
- Flow Cytometry
- Genetic Variation
- Humans
- Leukocyte Common Antigens
- Male
- Polymorphism, Genetic
- Reference Values
- T-Lymphocytes