Article
Competitive and cooperative interactions in receptor signaling complexes.
The Journal of biological chemistry - 13 Oct 2006
Asinas Abdalin E, Weis Robert M
Abstract excerpt
In bacterial chemotaxis, clustered transmembrane receptors and the adaptor protein CheW regulate the kinase CheA. Receptors outnumber CheA, yet it is poorly understood how interactions among receptors contribute to regulation. To address this problem, receptor clusters were simulated using liposomes decorated with the cytoplasmic domains of receptors, which supported CheA binding and stimulation. Competitive and...
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